SENSITIVITY OF GENOME-WIDE-ASSOCIATION SIGNALS TO PHENOTYPING STRATEGY: THE PROP-TAS2R38 TASTE ASSOCIATION AS A BENCHMARK.

Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark.

Natural genetic variation can have a pronounced influence on human taste perception, which in turn may influence food preference and dietary choice.Genome-wide association studies represent a powerful tool to understand this influence.To help optimize the design of future genome-wide-association studies on human taste perception Leather Biker Jacke

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Standardised practices in the networked management of congenital hyperinsulinism: a UK national collaborative consensus

Congenital hyperinsulinism (CHI) is a condition characterised by severe and recurrent hypoglycaemia in infants and young children caused by inappropriate insulin over-secretion.CHI is of heterogeneous aetiology with a significant genetic component and is often unresponsive to standard medical therapy options.The treatment of CHI can be multifaceted

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Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum.

Conventional autophagy is a lysosome-dependent degradation process that has crucial homeostatic and regulatory functions in eukaryotic organisms.As malaria parasites must dispose a number of self and host cellular contents, we investigated if autophagy in malaria parasites is similar to the conventional autophagy.Genome wide analysis revealed a par

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Behavior and hippocampal Epac signaling to nicotine CPP in mice

Tobacco use is a major challenge to public health in the United States and across the world.Many studies have demonstrated that adult men and women differ in their responses to tobacco smoking, however neurobiological parts studies about the effect of smoking on males and females were limited.Exchange protein directly activated by cAMP (Epac) signa

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Increased Uptake of HCV Testing through a Community-Based Educational Intervention in Difficult-to-Reach People Who Inject Drugs: Results from the ANRS-AERLI Study.

AIMS:The community-based AERLI intervention provided training and education to people who inject drugs (PWID) about HIV and HCV transmission risk reduction, with a focus on drug injecting practices, other injection-related complications, and access to HIV and HCV testing and care.We hypothesized that in such a population where HCV prevalence is ver

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